2GYO

Methanethiol-Cys 112 Inhibition Complex of E. Coli Ketoacyl Synthase III (FabH) and Coenzyme A

2GYO の概要

• エントリーDOI: 10.2210/pdb2gyo/pdb
• 関連するPDBエントリー: 1EBL 1HND
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 3, COENZYME A, METHANETHIOL, ... (5 entities in total)
• 機能のキーワード: fatty acid biosynthesis, alkyl-coa-disulfide, mechanism-based inhibitor, mycobacterium tuberculosis, transferase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A6R0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68101.82

構造登録者

Alhamadsheh, M.M.,Musayev, F.,Komissarov, A.A.,Sachdeva, S.,Wright, H.T.,Scarsdale, N.,Florova, G.,Reynolds, K.A. (登録日: 2006-05-09, 公開日: 2007-06-05, 最終更新日: 2011-07-13)

• 主引用文献: Alhamadsheh, M.M.,Musayev, F.,Komissarov, A.A.,Sachdeva, S.,Wright, H.T.,Scarsdale, N.,Florova, G.,Reynolds, K.A.; Alkyl-CoA Disulfides as Inhibitors and Mechanistic Probes for FabH Enzymes.; Chem.Biol., 14:513-524, 2007; PubMed: 17524982; DOI: 10.1016/j.chembiol.2007.03.013

実験手法

X-RAY DIFFRACTION (2 Å)