2GX4
Crystal structure of SARS coronavirus 3CL protease inhibitor complex
Summary for 2GX4
Entry DOI | 10.2210/pdb2gx4/pdb |
Related | 1Z1I 1Z1J |
Descriptor | 3C-like proteinase, N-[(BENZYLOXY)CARBONYL]-O-(TERT-BUTYL)-L-THREONYL-3-CYCLOHEXYL-N-[(1S)-2-HYDROXY-1-{[(3S)-2-OXOPYRROLIDIN-3-YL]METHYL}ETHYL]-L-ALANINAMIDE (3 entities in total) |
Functional Keywords | sars, 3cl protease, inhibitor complex, hydrolase |
Biological source | SARS coronavirus |
Total number of polymer chains | 1 |
Total formula weight | 34479.40 |
Authors | Hsu, M.F.,Wang, A.H.-J. (deposition date: 2006-05-08, release date: 2007-05-08, Last modification date: 2020-04-08) |
Primary citation | Yang, S.,Chen, S.J.,Hsu, M.F.,Wu, J.D.,Tseng, C.T.,Liu, Y.F.,Chen, H.C.,Kuo, C.W.,Wu, C.S.,Chang, L.W.,Chen, W.C.,Liao, S.Y.,Chang, T.Y.,Hung, H.H.,Shr, H.L.,Liu, C.Y.,Huang, Y.A.,Chang, L.Y.,Hsu, J.C.,Peters, C.J.,Wang, A.H.,Hsu, M.C. Synthesis, crystal structure, structure-activity relationships, and antiviral activity of a potent SARS coronavirus 3CL protease inhibitor. J.Med.Chem., 49:4971-4980, 2006 Cited by PubMed: 16884309DOI: 10.1021/jm0603926 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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