Crystal Structure of human NMPRTase and its complex with NMN

Summary for 2GVG

DescriptorNicotinamide phosphoribosyltransferase, PHOSPHATE ION, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, ... (4 entities in total)
Functional Keywordsnmprtase, visfatin, pbef, crystal, cancer, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm (By similarity) P43490
Total number of polymer chains6
Total molecular weight336720.64
Khan, J.A.,Tao, X.,Tong, L. (deposition date: 2006-05-02, release date: 2006-06-20, Last modification date: 2011-07-13)
Primary citation
Khan, J.A.,Tao, X.,Tong, L.
Molecular basis for the inhibition of human NMPRTase, a novel target for anticancer agents.
Nat.Struct.Mol.Biol., 13:582-588, 2006
PubMed: 16783377 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb1105
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.244150.4%4.0%1.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2gvg
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Molmil generated image of 2gvg
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Molmil generated image of 2gvg
rotated about y axis by 90°