2GQG

X-ray Crystal Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain

2GQG の概要

• エントリーDOI: 10.2210/pdb2gqg/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase ABL1, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: kinase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytoskeleton. Isoform IB: Nucleus membrane; Lipid-anchor: P00519
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 65503.58

構造登録者

Klei, H.E. (登録日: 2006-04-20, 公開日: 2006-11-21, 最終更新日: 2017-10-18)

• 主引用文献: Tokarski, J.S.,Newitt, J.,Chang, C.Y.J.,Cheng, J.D.,Wittekind, M.,Kiefer, S.E.,Kish, K.,Lee, F.Y.F.,Borzilerri, R.,Lombardo, L.J.,Xie, D.,Zhang, Y.,Klei, H.E.; The Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain Elucidates Its Inhibitory Activity against Imatinib-Resistant ABL Mutants; CANCER RES., 66:5790-5797, 2006; PubMed: 16740718; DOI: 10.1158/0008-5472.CAN-05-4187

実験手法

X-RAY DIFFRACTION (2.4 Å)