2GQ2
Mycobacterium tuberculosis ThyX-NADP complex
Summary for 2GQ2
Entry DOI | 10.2210/pdb2gq2/pdb |
Related | 2AF6 |
Descriptor | Thymidylate synthase thyX, IODIDE ION, POTASSIUM ION, ... (7 entities in total) |
Functional Keywords | m.tuberculosis, thyx, fdts, tscp, flavin dependent thymidylate synthase, inhibitor design, bivalent drugs, transferase |
Biological source | Mycobacterium tuberculosis H37Rv |
Total number of polymer chains | 4 |
Total formula weight | 121708.31 |
Authors | Sampathkumar, P.,Turley, S.,Sibley, C.H.,Hol, W.G. (deposition date: 2006-04-19, release date: 2006-06-27, Last modification date: 2023-11-15) |
Primary citation | Sampathkumar, P.,Turley, S.,Sibley, C.H.,Hol, W.G. NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design. J.Mol.Biol., 360:1-6, 2006 Cited by PubMed: 16730023DOI: 10.1016/j.jmb.2006.04.061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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