2GQ2

Mycobacterium tuberculosis ThyX-NADP complex

Summary for 2GQ2

Related2AF6
DescriptorThymidylate synthase thyX, IODIDE ION, POTASSIUM ION, ... (7 entities in total)
Functional Keywordsm.tuberculosis, thyx, fdts, tscp, flavin dependent thymidylate synthase, inhibitor design, bivalent drugs, transferase
Biological sourceMycobacterium tuberculosis H37Rv
Total number of polymer chains4
Total molecular weight121708.31
Authors
Sampathkumar, P.,Turley, S.,Sibley, C.H.,Hol, W.G. (deposition date: 2006-04-19, release date: 2006-06-27, Last modification date: 2011-07-13)
Primary citation
Sampathkumar, P.,Turley, S.,Sibley, C.H.,Hol, W.G.
NADP+ expels both the co-factor and a substrate analog from the Mycobacterium tuberculosis ThyX active site: opportunities for anti-bacterial drug design.
J.Mol.Biol., 360:1-6, 2006
PubMed: 16730023 (PDB entries with the same primary citation)
DOI: 10.1016/j.jmb.2006.04.061
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.210100.3%2.1%5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution