2GMX

Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity

2GMX の概要

関連するPDBエントリー2g01
分子名称Mitogen-activated protein kinase 8, C-jun-amino-terminal kinase-interacting protein 1, SULFATE ION, ... (4 entities in total)
機能のキーワードjnk1, c-jun n-terminal kinase, protein kinase jnk1 inhibitors, aminopyridine-based c-jun n-terminal kinase inhibitors, transcription
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Cytoplasm (By similarity) Q9UQF2
ポリマー鎖数4
分子量合計89785.14
構造登録者
Abad-Zapatero, C. (登録日: 2006-04-07, 公開日: 2006-06-06, 最終更新日: 2011-07-13)
主引用文献
Szczepankiewicz, B.G.,Kosogof, C.,Nelson, L.T.,Liu, G.,Liu, B.,Zhao, H.,Serby, M.D.,Xin, Z.,Liu, M.,Gum, R.J.,Haasch, D.L.,Wang, S.,Clampit, J.E.,Johnson, E.F.,Lubben, T.H.,Stashko, M.A.,Olejniczak, E.T.,Sun, C.,Dorwin, S.A.,Haskins, K.,Abad-Zapatero, C.,Fry, E.H.,Hutchins, C.W.,Sham, H.L.,Rondinone, C.M.,Trevillyan, J.M.
Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity.
J.Med.Chem., 49:3563-3580, 2006
PubMed: 16759099 (主引用文献が同じPDBエントリー)
DOI: 10.1021/jm060199b
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3.5 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers6015.5%10.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード