2GMX

Selective Aminopyridine-Based C-Jun N-terminal Kinase inhibitors with cellular activity

2GMX の概要

• エントリーDOI: 10.2210/pdb2gmx/pdb
• 関連するPDBエントリー: 2g01
• 分子名称: Mitogen-activated protein kinase 8, C-jun-amino-terminal kinase-interacting protein 1, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: jnk1, c-jun n-terminal kinase, protein kinase jnk1 inhibitors, aminopyridine-based c-jun n-terminal kinase inhibitors, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm (By similarity): Q9UQF2
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 89785.14

構造登録者

Abad-Zapatero, C. (登録日: 2006-04-07, 公開日: 2006-06-06, 最終更新日: 2023-08-30)

• 主引用文献: Szczepankiewicz, B.G.,Kosogof, C.,Nelson, L.T.,Liu, G.,Liu, B.,Zhao, H.,Serby, M.D.,Xin, Z.,Liu, M.,Gum, R.J.,Haasch, D.L.,Wang, S.,Clampit, J.E.,Johnson, E.F.,Lubben, T.H.,Stashko, M.A.,Olejniczak, E.T.,Sun, C.,Dorwin, S.A.,Haskins, K.,Abad-Zapatero, C.,Fry, E.H.,Hutchins, C.W.,Sham, H.L.,Rondinone, C.M.,Trevillyan, J.M.; Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity.; J.Med.Chem., 49:3563-3580, 2006; PubMed: 16759099; DOI: 10.1021/jm060199b

実験手法

X-RAY DIFFRACTION (3.5 Å)