2GMT

THREE-DIMENSIONAL STRUCTURE OF CHYMOTRYPSIN INACTIVATED WITH (2S) N-ACETYL-L-ALANYL-L-PHENYLALANYL-CHLOROETHYL KETONE: IMPLICATIONS FOR THE MECHANISM OF INACTIVATION OF SERINE PROTEASES BY CHLOROKETONES

2GMT の概要

• エントリーDOI: 10.2210/pdb2gmt/pdb
• 分子名称: GAMMA-CHYMOTRYPSIN, (2S) N-ACETYL-L-ALANYL-ALPHAL-PHENYLALANYL-CHLOROETHYLKETONE, ... (5 entities in total)
• 機能のキーワード: hydrolase(serine proteinase)
• 由来する生物種: Bos taurus (cattle)
• 細胞内の位置: Secreted, extracellular space: P00766 P00766 P00766
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 25587.37

構造登録者

Kreutter, K.,Steinmetz, A.C.U.,Liang, T.-C.,Prorok, M.,Abeles, R.,Ringe, D. (登録日: 1994-09-07, 公開日: 1994-11-01, 最終更新日: 2024-06-05)

• 主引用文献: Kreutter, K.,Steinmetz, A.C.,Liang, T.C.,Prorok, M.,Abeles, R.H.,Ringe, D.; Three-dimensional structure of chymotrypsin inactivated with (2S)-N-acetyl-L-alanyl-L-phenylalanyl alpha-chloroethane: implications for the mechanism of inactivation of serine proteases by chloroketones.; Biochemistry, 33:13792-13800, 1994; PubMed: 7947790; DOI: 10.1021/bi00250a033

実験手法

X-RAY DIFFRACTION (1.8 Å)