2GK3

Cytoplasmic Protein STM3548 from Salmonella typhimurium

2GK3 の概要

• エントリーDOI: 10.2210/pdb2gk3/pdb
• 分子名称: putative cytoplasmic protein, GLYCEROL (3 entities in total)
• 機能のキーワード: salmonella typhimurium, stm3548, structural genomics, psi, protein structure initiative, midwest center for structural genomics, mcsg, unknown function
• 由来する生物種: Salmonella typhimurium
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 175943.91

構造登録者

Petrova, T.,Cuff, M.E.,Wu, R.Y.,Holzle, D.,Joachimiak, A.,Midwest Center for Structural Genomics (MCSG) (登録日: 2006-03-31, 公開日: 2006-05-02, 最終更新日: 2024-10-30)

主引用文献

Petrova, T.,Cuff, M.E.,Wu, R.,Kim, Y.,Holzle, D.,Joachimiak, A.
Novel hexamerization motif is discovered in a conserved cytoplasmic protein from Salmonella typhimurium.
J.Struct.Funct.Genom., 8:19-25, 2007

PubMed Abstract: The cytoplasmic protein Stm3548 of unknown function obtained from a strain of Salmonella typhimurium was determined by X-ray crystallography at a resolution of 2.25 A. The asymmetric unit contains a hexamer of structurally identical monomers. The monomer is a globular domain with a long beta-hairpin protrusion that distinguishes this structure. This beta-hairpin occupies a central position in the hexamer, and its residues participate in the majority of interactions between subunits of the hexamer. We suggest that the structure of Stm3548 presents a new hexamerization motif. Because the residues participating in interdomain interactions are highly conserved among close members of protein family DUF1355 and buried solvent accessible area for the hexamer is significant, the hexamer is most likely conserved as well. A light scattering experiment confirmed the presence of hexamer in solution.

PubMed: 17968677
DOI: 10.1007/s10969-007-9028-1

実験手法

X-RAY DIFFRACTION (2.25 Å)