2GH0

Growth factor/receptor complex

2GH0 の概要

• エントリーDOI: 10.2210/pdb2gh0/pdb
• 分子名称: artemin, GDNF family receptor alpha-3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: cystine-knot, helix bundle, hormone-growth factor complex, hormone/growth factor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 70604.52

構造登録者

Wang, X.Q. (登録日: 2006-03-24, 公開日: 2006-06-27, 最終更新日: 2024-10-09)

主引用文献

Wang, X.,Baloh, R.H.,Milbrandt, J.,Garcia, K.C.
Structure of Artemin Complexed with Its Receptor GFRalpha3: Convergent Recognition of Glial Cell Line-Derived Neurotrophic Factors.
Structure, 14:1083-1092, 2006

PubMed Abstract: Artemin (ARTN) is a member of the glial cell line-derived neurotrophic factor (GDNF) family ligands (GFLs) which regulate the development and maintenance of many neuronal populations in the mammalian nervous system. Here we report the 1.92 A crystal structure of the complex formed between ARTN and its receptor GFRalpha3, which is the initiating step in the formation of a ternary signaling complex containing the shared RET receptor. It represents a new receptor-ligand interaction mode for the TGF-beta superfamily that reveals both conserved and specificity-determining anchor points for all GFL-GFRalpha pairs. In tandem with the complex structure, cellular studies using receptor chimeras implicate dyad-symmetric composite interfaces for recruitment and dimerization of RET, leading to intracellular signaling. These studies should facilitate the functional dissection of the specific versus pleiotropic roles of this system in neurobiology, as well as its exploitation for therapeutic applications.

PubMed: 16765900
DOI: 10.1016/j.str.2006.05.010

実験手法

X-RAY DIFFRACTION (1.92 Å)