2GFB

CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE-LIKE ACTIVITY

Summary for 2GFB

• Entry DOI: 10.2210/pdb2gfb/pdb
• Descriptor: IGG2A CNJ206 FAB (LIGHT CHAIN), IGG2A CNJ206 FAB (HEAVY CHAIN) (2 entities in total)
• Functional Keywords: immunoglobulin
• Biological source: Mus musculus (house mouse); More
• Total number of polymer chains: 16
• Total formula weight: 374864.39

Authors

Golinelli-Pimpaneau, B.,Knossow, M. (deposition date: 1994-07-07, release date: 1994-09-30, Last modification date: 2024-10-30)

Primary citation

Golinelli-Pimpaneau, B.,Gigant, B.,Bizebard, T.,Navaza, J.,Saludjian, P.,Zemel, R.,Tawfik, D.S.,Eshhar, Z.,Green, B.S.,Knossow, M.
Crystal structure of a catalytic antibody Fab with esterase-like activity.
Structure, 2:175-183, 1994

PubMed Abstract: Antibodies with catalytic properties can be prepared by eliciting an antibody response against 'transition state analog' haptens. The specificity, rate and number of reaction cycles observed with these antibodies more closely resemble the properties of enzymes than any of the many other known enzyme-mimicking systems.

PubMed: 8069632
DOI: 10.1016/S0969-2126(00)00019-8

Experimental method

X-RAY DIFFRACTION (3 Å)