2GFB

CRYSTAL STRUCTURE OF A CATALYTIC FAB HAVING ESTERASE-LIKE ACTIVITY

2GFB の概要

• エントリーDOI: 10.2210/pdb2gfb/pdb
• 分子名称: IGG2A CNJ206 FAB (LIGHT CHAIN), IGG2A CNJ206 FAB (HEAVY CHAIN) (2 entities in total)
• 機能のキーワード: immunoglobulin
• 由来する生物種: Mus musculus (house mouse); 詳細
• タンパク質・核酸の鎖数: 16
• 化学式量合計: 374864.39

構造登録者

Golinelli-Pimpaneau, B.,Knossow, M. (登録日: 1994-07-07, 公開日: 1994-09-30, 最終更新日: 2024-10-30)

主引用文献

Golinelli-Pimpaneau, B.,Gigant, B.,Bizebard, T.,Navaza, J.,Saludjian, P.,Zemel, R.,Tawfik, D.S.,Eshhar, Z.,Green, B.S.,Knossow, M.
Crystal structure of a catalytic antibody Fab with esterase-like activity.
Structure, 2:175-183, 1994

PubMed Abstract: Antibodies with catalytic properties can be prepared by eliciting an antibody response against 'transition state analog' haptens. The specificity, rate and number of reaction cycles observed with these antibodies more closely resemble the properties of enzymes than any of the many other known enzyme-mimicking systems.

PubMed: 8069632
DOI: 10.1016/S0969-2126(00)00019-8

実験手法

X-RAY DIFFRACTION (3 Å)