2GF1

SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY

2GF1 の概要

• エントリーDOI: 10.2210/pdb2gf1/pdb
• 分子名称: INSULIN-LIKE GROWTH FACTOR I (1 entity in total)
• 機能のキーワード: growth factor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7663.75

構造登録者

Cooke, R.M.,Harvey, T.S.,Campbell, I.D. (登録日: 1991-01-23, 公開日: 1993-04-15, 最終更新日: 2024-10-16)

主引用文献

Cooke, R.M.,Harvey, T.S.,Campbell, I.D.
Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study.
Biochemistry, 30:5484-5491, 1991

PubMed Abstract: The solution structure of human insulin-like growth factor 1 has been investigated with a combination of nuclear magnetic resonance and restrained molecular dynamics methods. The results show that the solution structure is similar to that of insulin, but minor differences exist. The regions homologous to insulin are well-defined, while the remainder of the molecule exhibits greater disorder. The resultant structures have been used to visualize the sites for interaction with a number of physiologically important proteins.

PubMed: 2036417
DOI: 10.1021/bi00236a022

実験手法

SOLUTION NMR