2GCU

X-Ray Structure of Gene Product from Arabidopsis Thaliana At1g53580

2GCU の概要

• エントリーDOI: 10.2210/pdb2gcu/pdb
• 分子名称: Putative hydroxyacylglutathione hydrolase 3, FE (II) ION, SULFATE ION, ... (5 entities in total)
• 機能のキーワード: ethylmalonic encephalopathy, ethe1, structural genomics, protein structure initiative, psi, center for eukaryotic structural genomics, cesg, hydrolase
• 由来する生物種: Arabidopsis thaliana (thale cress)
• 細胞内の位置: Mitochondrion : Q9C8L4
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 108986.98

構造登録者

McCoy, J.G.,Wesenberg, G.E.,Phillips Jr., G.N.,Bitto, E.,Bingman, C.A.,Center for Eukaryotic Structural Genomics (CESG) (登録日: 2006-03-14, 公開日: 2006-04-18, 最終更新日: 2024-10-30)

主引用文献

McCoy, J.G.,Bingman, C.A.,Bitto, E.,Holdorf, M.M.,Makaroff, C.A.,Phillips, G.N.
Structure of an ETHE1-like protein from Arabidopsis thaliana.
ACTA CRYSTALLOGR.,SECT.D, 62:964-970, 2006

PubMed Abstract: The protein product of gene At1g53580 from Arabidopsis thaliana possesses 54% sequence identity to a human enzyme that has been implicated in the rare disorder ethylmalonic encephalopathy. The structure of the At1g53580 protein has been solved to a nominal resolution of 1.48 Angstrom. This structure reveals tertiary structure differences between the ETHE1-like enzyme and glyoxalase II enzymes that are likely to account for differences in reaction chemistry and multimeric state between the two types of enzymes. In addition, the Arabidopsis ETHE1 protein is used as a model to explain the significance of several mutations in the human enzyme that have been observed in patients with ethylmalonic encephalopathy.

PubMed: 16929096
DOI: 10.1107/S0907444906020592

実験手法

X-RAY DIFFRACTION (1.477 Å)