2G7H

Structure of an O6-Methylguanine DNA Methyltransferase from Methanococcus jannaschii (MJ1529)

2G7H の概要

• エントリーDOI: 10.2210/pdb2g7h/pdb
• NMR情報: BMRB: 7122
• 分子名称: Methylated-DNA--protein-cysteine methyltransferase (1 entity in total)
• 機能のキーワード: protein structure, dna repair, dna methyltransferase, transferase
• 由来する生物種: Methanocaldococcus jannaschii
• 細胞内の位置: Cytoplasm (By similarity): Q58924
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 19460.94

構造登録者

Roberts, A. (登録日: 2006-02-28, 公開日: 2006-08-01, 最終更新日: 2024-05-29)

主引用文献

Roberts, A.,Pelton, J.G.,Wemmer, D.E.
Structural studies of MJ1529, an O(6)-methylguanine-DNA methyltransferase
Magn.Reson.Chem., 44:71-82, 2006

PubMed Abstract: The structure of an O6-methylguanine-DNA methyltransferase (MGMT) from the thermophile Methanococcus jannaschii has been determined using multinuclear multidimensional NMR spectroscopy. The structure is similar to homologs from other organisms that have been determined by crystallography, with some variation in the N-terminal domain. The C-terminal domain is more highly conserved in both sequence and structure. Regions of the protein show broadening, reflecting conformational flexibility that is likely related to function.

PubMed: 16826543
DOI: 10.1002/mrc.1823

実験手法

SOLUTION NMR