2G71
Structure of hPNMT with inhibitor 3-fluoromethyl-7-trifluoropropyl-THIQ and AdoHcy
Summary for 2G71
Entry DOI | 10.2210/pdb2g71/pdb |
Related | 1HNN 1N7I 1N7J 1YZ3 2g70 2g72 |
Descriptor | Phenylethanolamine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, (3R)-3-(FLUOROMETHYL)-N-(3,3,3-TRIFLUOROPROPYL)-1,2,3,4-TETRAHYDROISOQUINOLINE-7-SULFONAMIDE, ... (5 entities in total) |
Functional Keywords | methyltransferase, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65233.52 |
Authors | Tyndall, J.D.A.,Gee, C.L.,Martin, J.L. (deposition date: 2006-02-27, release date: 2007-02-13, Last modification date: 2023-10-25) |
Primary citation | Gee, C.L.,Drinkwater, N.,Tyndall, J.D.A.,Grunewald, G.L.,Wu, Q.,McLeish, M.J.,Martin, J.L. Enzyme Adaptation to Inhibitor Binding: A Cryptic Binding Site in Phenylethanolamine N-Methyltransferase J.Med.Chem., 50:4845-4853, 2007 Cited by PubMed: 17845018DOI: 10.1021/jm0703385 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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