2G1Z

X-ray structure of the oligonucleotide sequence d(AAATTT)

Summary for 2G1Z

Entry DOI	10.2210/pdb2g1z/pdb
Descriptor	5'-D(APAPAPTPTPT)-3' (1 entity in total)
Functional Keywords	oligonucleotide, adenine, thymine, dna
Total number of polymer chains	3
Total formula weight	5421.72
Authors	Valls, N.,Santaolalla, A.,Campos, J.L.,Subirana, J.A. (deposition date: 2006-02-15, release date: 2006-03-21, Last modification date: 2024-03-13)
Primary citation	Valls, N.,Santaolalla, A.,Campos, J.L.,Subirana, J.A. Packing features of the all-AT oligonucleotide d(AAATTT). J.Biomol.Struct.Dyn., 24:547-552, 2007 Cited by PubMed Abstract: We describe the packing features of the oligonucleotide duplex d(AAATTT)2, as determined by X-ray diffraction. There is little information on sequences that only contain A and T bases. The present structure confirms that these sequences tend to pack as a helical arrangement of stacked oligonucleotides in a B conformation with Watson-Crick hydrogen bonding. Our results demonstrate that the virtual TA base step between stacked duplexes has a negative twist that improves base stacking. This observation is consistent with the low stability of TA base steps in B-form DNA. PubMed: 17508776 DOI: 10.1080/07391102.2007.10507143 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.11 Å)

Structure validation