2G1Z

X-ray structure of the oligonucleotide sequence d(AAATTT)

2G1Z の概要

• エントリーDOI: 10.2210/pdb2g1z/pdb
• 分子名称: 5'-D(*AP*AP*AP*TP*TP*T)-3' (1 entity in total)
• 機能のキーワード: oligonucleotide, adenine, thymine, dna
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 5421.72

構造登録者

Valls, N.,Santaolalla, A.,Campos, J.L.,Subirana, J.A. (登録日: 2006-02-15, 公開日: 2006-03-21, 最終更新日: 2024-03-13)

主引用文献

Valls, N.,Santaolalla, A.,Campos, J.L.,Subirana, J.A.
Packing features of the all-AT oligonucleotide d(AAATTT).
J.Biomol.Struct.Dyn., 24:547-552, 2007

PubMed Abstract: We describe the packing features of the oligonucleotide duplex d(AAATTT)2, as determined by X-ray diffraction. There is little information on sequences that only contain A and T bases. The present structure confirms that these sequences tend to pack as a helical arrangement of stacked oligonucleotides in a B conformation with Watson-Crick hydrogen bonding. Our results demonstrate that the virtual TA base step between stacked duplexes has a negative twist that improves base stacking. This observation is consistent with the low stability of TA base steps in B-form DNA.

PubMed: 17508776
DOI: 10.1080/07391102.2007.10507143

実験手法

X-RAY DIFFRACTION (3.11 Å)