2G01

Pyrazoloquinolones as Novel, Selective JNK1 inhibitors

2G01 の概要

分子名称Mitogen-activated protein kinase 8, C-jun-amino-terminal kinase-interacting protein 1, SULFATE ION, ... (4 entities in total)
機能のキーワードjnk1, c-jun n-terminal kinase, protein kinase jnk1 inhibitors, transferase
由来する生物種Homo sapiens (human)
詳細
細胞内の位置Cytoplasm  P45983 Q9UQF2
ポリマー鎖数4
分子量合計89441.95
構造登録者
Abad-Zapatero, C. (登録日: 2006-02-10, 公開日: 2006-04-18, 最終更新日: 2018-03-14)
主引用文献
Liu, M.,Xin, Z.,Clampit, J.E.,Wang, S.,Gum, R.J.,Haasch, D.L.,Trevillyan, J.M.,Abad-Zapatero, C.,Fry, E.H.,Sham, H.L.,Liu, G.
Synthesis and SAR of 1,9-dihydro-9-hydroxypyrazolo[3,4-b]quinolin-4-ones as novel, selective c-Jun N-terminal kinase inhibitors.
Bioorg.Med.Chem.Lett., 16:2590-2594, 2006
PubMed: 16527482 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2006.02.046
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3.5 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers6413.1%10.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード