2FYZ

Structural of Mumps virus fusion protein core

Summary for 2FYZ

• Entry DOI: 10.2210/pdb2fyz/pdb
• Descriptor: Fusion glycoprotein F0 (3 entities in total)
• Functional Keywords: mumps virus fusion protein core, protein binding
• Biological source: Mumps virus; More
• Cellular location: Virion membrane; Single-pass type I membrane protein (By similarity): P11236 P11236
• Total number of polymer chains: 6
• Total formula weight: 35325.91

Authors

Lou, Z.,Xu, Y.,Liu, Y.,Rao, Z. (deposition date: 2006-02-08, release date: 2007-04-10, Last modification date: 2023-10-25)

Primary citation

Liu, Y.,Xu, Y.,Lou, Z.,Zhu, J.,Hu, X.,Gao, G.F.,Qiu, B.,Rao, Z.,Tien, P.
Structural characterization of mumps virus fusion protein core
Biochem.Biophys.Res.Commun., 348:916-922, 2006

PubMed Abstract: The fusion proteins of enveloped viruses mediating the fusion between the viral and cellular membranes comprise two discontinuous heptad repeat (HR) domains located at the ectodomain of the enveloped glycoproteins. The crystal structure of the fusion protein core of Mumps virus (MuV) was determined at 2.2 A resolution. The complex is a six-helix bundle in which three HR1 peptides form a central highly hydrophobic coiled-coil and three HR2 peptides pack against the hydrophobic grooves on the surface of central coiled-coil in an oblique antiparallel manner. Fusion core of MuV, like those of simian virus 5 and human respiratory syncytium virus, forms typical 3-4-4-4-3 spacing. The similar characterization in HR1 regions, as well as the existence of O-X-O motif in extended regions of HR2 helix, suggests a basic rule for the formation of the fusion core of viral fusion proteins.

PubMed: 16904649
DOI: 10.1016/j.bbrc.2006.07.168

Experimental method

X-RAY DIFFRACTION (2.2 Å)