2FXU

X-ray Structure of Bistramide A- Actin Complex at 1.35 A resolution.

2FXU の概要

• エントリーDOI: 10.2210/pdb2fxu/pdb
• 分子名称: Actin, alpha skeletal muscle, CALCIUM ION, ADENOSINE-5'-TRIPHOSPHATE, ... (5 entities in total)
• 機能のキーワード: actin complexed to bistramide a, structural protein
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• 細胞内の位置: Cytoplasm, cytoskeleton: P68135
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 43248.10

構造登録者

Rizvi, S.A.,Tereshko, V.,Kossiakoff, A.A.,Kozmin, S.A. (登録日: 2006-02-06, 公開日: 2006-03-07, 最終更新日: 2023-08-30)

主引用文献

Rizvi, S.A.,Tereshko, V.,Kossiakoff, A.A.,Kozmin, S.A.
Structure of bistramide a-actin complex at a 1.35 A resolution
J.Am.Chem.Soc., 128:3882-3883, 2006

PubMed Abstract: Bistramide A is a highly potent antiproliferative marine natural product from Lissoclinum bistratum. We have previously established actin as the primary cellular receptor of bistramide A. We report herein the X-ray structure of bistramide A bound to monomeric actin at a resolution of 1.35 A. The most notable aspect of the bistramide A-actin structure is an extensive hydrogen-bonding network established upon a deep penetration of the central segment of bistramide A into the actin-binding cleft between subdomains 1 and 3. The structure presents the first insight into the observed ability of bistramide A to modulate G-actin polymerization. The structural information combined with our ability to chemically modify the bistramide framework provides the basis for rational development of a series of new synthetic analogues as useful probes for studying actin cytoskeleton and as potential therapeutic leads.

PubMed: 16551075
DOI: 10.1021/ja058319c

実験手法

X-RAY DIFFRACTION (1.35 Å)