2FP7
West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H
2FP7 の概要
エントリーDOI | 10.2210/pdb2fp7/pdb |
関連するPDBエントリー | 2FOM |
関連するBIRD辞書のPRD_ID | PRD_000988 |
分子名称 | Genome polyprotein, N-benzoyl-L-norleucyl-L-lysyl-N-[(2S)-5-carbamimidamido-1-hydroxypentan-2-yl]-L-argininamide, ... (4 entities in total) |
機能のキーワード | flavivirus, ns3 protease, ns2b cofactor, substrate-based inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
由来する生物種 | West Nile virus (WNV) 詳細 |
細胞内の位置 | Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side : P06935 P06935 |
タンパク質・核酸の鎖数 | 3 |
化学式量合計 | 25353.52 |
構造登録者 | |
主引用文献 | Erbel, P.,Schiering, N.,D'Arcy, A.,Renatus, M.,Kroemer, M.,Lim, S.P.,Yin, Z.,Keller, T.H.,Vasudevan, S.G.,Hommel, U. Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus. Nat.Struct.Mol.Biol., 13:372-373, 2006 Cited by PubMed: 16532006DOI: 10.1038/nsmb1073 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (1.68 Å) |
構造検証レポート
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