2FJP
Human dipeptidyl peptidase IV/CD26 in complex with an inhibitor
2FJP の概要
エントリーDOI | 10.2210/pdb2fjp/pdb |
分子名称 | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
機能のキーワード | alpha/beta, beta-propeller, dimer, hydrolase |
由来する生物種 | Homo sapiens (human) |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 174949.10 |
構造登録者 | |
主引用文献 | Edmondson, S.D.,Mastracchio, A.,Mathvink, R.J.,He, J.,Harper, B.,Park, Y.J.,Beconi, M.,Di Salvo, J.,Eiermann, G.J.,He, H.,Leiting, B.,Leone, J.F.,Levorse, D.A.,Lyons, K.,Patel, R.A.,Patel, S.B.,Petrov, A.,Scapin, G.,Shang, J.,Roy, R.S.,Smith, A.,Wu, J.K.,Xu, S.,Zhu, B.,Thornberry, N.A.,Weber, A.E. (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J.Med.Chem., 49:3614-3627, 2006 Cited by PubMed: 16759103DOI: 10.1021/jm060015t 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.4 Å) |
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