2FIT

FHIT (FRAGILE HISTIDINE TRIAD PROTEIN)

2FIT の概要

• エントリーDOI: 10.2210/pdb2fit/pdb
• 分子名称: FRAGILE HISTIDINE PROTEIN, beta-D-fructofuranose, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: fhit, fragile histidine triad protein, putative human tumor suppressor, advanced photon source, aps, hit protein family, pkci, chromosomal translocation
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 17352.27

構造登録者

Lima, C.D.,D'Amico, K.L.,Naday, I.,Rosenbaum, G.,Westbrook, E.M.,Hendrickson, W.A. (登録日: 1997-05-17, 公開日: 1997-11-19, 最終更新日: 2024-10-16)

主引用文献

Lima, C.D.,D'Amico, K.L.,Naday, I.,Rosenbaum, G.,Westbrook, E.M.,Hendrickson, W.A.
MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family.
Structure, 5:763-774, 1997

PubMed Abstract: The fragile histidine triad (FHIT) protein is a member of the large and ubiquitous histidine triad (HIT) family of proteins. It is expressed from a gene located at a fragile site on human chromosome 3, which is commonly disrupted in association with certain cancers. On the basis of the genetic evidence, it has been postulated that the FHIT protein may function as a tumor suppressor, implying a role for the FHIT protein in carcinogenesis. The FHIT protein has dinucleoside polyphosphate hydrolase activity in vitro, thus suggesting that its role in vivo may involve the hydrolysis of a phosphoanhydride bond. The structural analysis of FHIT will identify critical residues involved in substrate binding and catalysis, and will provide insights into the in vivo function of HIT proteins.

PubMed: 9261067
DOI: 10.1016/S0969-2126(97)00231-1

実験手法

X-RAY DIFFRACTION (1.9 Å)