2FGV

X-ray crystal structure of HIV-1 Protease T80N variant in complex with the inhibitor saquinavir used to explore the role of invariant Thr80 in HIV-1 protease structure, function, and viral infectivity.

2FGV の概要

• エントリーDOI: 10.2210/pdb2fgv/pdb
• 関連するPDBエントリー: 2FGU
• 分子名称: Protease, PHOSPHATE ION, quinoline-2-carboxylic acid, ... (8 entities in total)
• 機能のキーワード: hiv protease, drug resistance, enzyme kinetics, sequence conservation, protein structure, hydrolase
• 由来する生物種: Human immunodeficiency virus 1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 23037.22

構造登録者

Foulkes, J.E.,Prabu-Jeyabalan, M.,Cooper, D.,Schiffer, C.A. (登録日: 2005-12-22, 公開日: 2006-11-07, 最終更新日: 2023-08-30)

• 主引用文献: Foulkes, J.E.,Prabu-Jeyabalan, M.,Cooper, D.,Henderson, G.J.,Harris, J.,Swanstrom, R.,Schiffer, C.A.; Role of invariant Thr80 in human immunodeficiency virus type 1 protease structure, function, and viral infectivity.; J.Virol., 80:6906-6916, 2006; PubMed: 16809296; DOI: 10.1128/JVI.01900-05

実験手法

X-RAY DIFFRACTION (1.5 Å)