2FGT

Crystal Structure of YycH from Bacillus subtilis

Summary for 2FGT

• Entry DOI: 10.2210/pdb2fgt/pdb
• Descriptor: Two-component system yycF/yycG regulatory protein yycH (2 entities in total)
• Functional Keywords: signal transduction, yych, calcium binding, beta sheet, signaling protein
• Biological source: Bacillus subtilis
• Cellular location: Cell membrane ; Single-pass membrane protein : Q794W0
• Total number of polymer chains: 1
• Total formula weight: 47943.71

Authors

Szurmant, H.,Zhao, H.,Mohan, M.A.,James, H.A.,Varughese, K.I. (deposition date: 2005-12-22, release date: 2006-04-25, Last modification date: 2024-02-14)

Primary citation

Szurmant, H.,Zhao, H.,Mohan, M.A.,Hoch, J.A.,Varughese, K.I.
The crystal structure of YycH involved in the regulation of the essential YycFG two-component system in Bacillus subtilis reveals a novel tertiary structure.
Protein Sci., 15:929-934, 2006

PubMed Abstract: The Bacillus subtilis YycFG two-component signal transduction system is essential for cell viability, and the YycH protein is part of the regulatory circuit that controls its activity. The crystal structure of YycH was solved by two-wavelength selenium anomalous dispersion data, and was refined using 2.3 A data to an R-factor of 25.2%. The molecule is made up of three domains, and has a novel three-dimensional structure. The N-terminal domain features a calcium binding site and the central domain contains two conserved loop regions.

PubMed: 16600972
DOI: 10.1110/ps.052064406

Experimental method

X-RAY DIFFRACTION (2.3 Å)