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2FF5

Synthesis of C-D-Glycopyranosyl-Hydroquinones and-Benzoquinones. Inhibition of PTP1B. Inhibition of and binding to glycogen phosphorylase in the crystal

Summary for 2FF5
Entry DOI10.2210/pdb2ff5/pdb
DescriptorGlycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, (1S)-1,5-anhydro-1-(2,5-dihydroxyphenyl)-D-glucitol, ... (4 entities in total)
Functional Keywordsglycogenolysis; type 2 diabetes, transferase
Biological sourceOryctolagus cuniculus (rabbit)
Total number of polymer chains1
Total formula weight97810.60
Authors
Chrysina, E.D.,Kosmopoulou, M.N.,Leonidas, D.D.,Oikonomakos, N.G. (deposition date: 2005-12-19, release date: 2006-12-19, Last modification date: 2023-08-30)
Primary citationHe, L.,Zhang, Y.Z.,Tanoh, M.,Chen, G.-R.,Praly, J.-P.,Chrysina, E.D.,Tiraidis, C.,Kosmopoulou, M.,Leonidas, D.D.,Oikonomakos, N.G.
In the Search of Glycogen Phosphorylase Inhibitors: Synthesis of C-D-Glycopyranosylbenzo(hydro)quinones Inhibition of and Binding to Glycogen Phosphorylase in the Crystal
Eur.J.Org.Chem., 4:596-606, 2007
Cited by
DOI: 10.1002/ejoc.200600548
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.03 Å)
Structure validation

217705

數據於2024-03-27公開中

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