2FET

Synthesis of C-D-Glycopyranosyl-Hydroquinones and-Benzoquinones. Inhibition of PTP1B. Inhibition of and binding to glycogen phosphorylase in the crystal

2FET の概要

• エントリーDOI: 10.2210/pdb2fet/pdb
• 分子名称: Glycogen phosphorylase, muscle form, PYRIDOXAL-5'-PHOSPHATE, (1S)-1,5-anhydro-1-(2,5-dihydroxyphenyl)-D-glucitol, ... (4 entities in total)
• 機能のキーワード: glycogenolysis; type 2 diabetes, transferase
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97810.60

構造登録者

Chrysina, E.D.,Kosmopoulou, M.N.,Leonidas, D.D.,Oikonomakos, N.G. (登録日: 2005-12-16, 公開日: 2006-12-19, 最終更新日: 2023-08-30)

• 主引用文献: He, L.,Zhang, Y.Z.,Tanoh, M.,Chen, G.-R.,Praly, J.-P.,Chrysina, E.D.,Tiraidis, C.,Kosmopoulou, M.,Leonidas, D.D.,Oikonomakos, N.G.; In the Search of Glycogen Phosphorylase Inhibitors: Synthesis of C-D-Glycopyranosylbenzo(hydro)quinones Inhibition of and Binding to Glycogen Phosphorylase in the Crystal; Eur.J.Org.Chem., 4:596-606, 2007; DOI: 10.1002/ejoc.200600548

実験手法

X-RAY DIFFRACTION (2.03 Å)