2FBE

Crystal Structure of the PRYSPRY-domain

2FBE の概要

• エントリーDOI: 10.2210/pdb2fbe/pdb
• 分子名称: PREDICTED: similar to ret finger protein-like 1 (2 entities in total)
• 機能のキーワード: dimer, jellyroll beta-sandwich fold, unknown function
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 89726.94

構造登録者

Gruetter, C.,Briand, C.,Capitani, G.,Mittl, P.R.,Gruetter, M.G. (登録日: 2005-12-09, 公開日: 2006-01-10, 最終更新日: 2024-11-06)

主引用文献

Gruetter, C.,Briand, C.,Capitani, G.,Mittl, P.R.,Papin, S.,Tschopp, J.,Gruetter, M.G.
Structure of the PRYSPRY-domain: Implications for autoinflammatory diseases
Febs Lett., 580:99-106, 2006

PubMed Abstract: We determined the first structure of PRYSPRY, a domain found in over 500 different proteins, involved in innate immune signaling, cytokine signaling suppression, development, cell growth and retroviral restriction. The fold encompasses a 7-stranded and a 6-stranded antiparallel beta-sheet, arranged in a beta-sandwich. In the crystal, PRYSPRY forms a dimer where the C-terminus of an acceptor molecule binds to the concave surface of a donor molecule, which represents a putative interaction site. Mutations in the PRYSPRY domains of Pyrin, which are responsible for familial Mediterranean fever, map on the putative PRYSPRY interaction site.

PubMed: 16364311
DOI: 10.1016/j.febslet.2005.11.076

実験手法

X-RAY DIFFRACTION (2.52 Å)