2FAV

Crystal structure of SARS macro domain in complex with ADP-ribose at 1.8 A resolution

Summary for 2FAV

• Entry DOI: 10.2210/pdb2fav/pdb
• Descriptor: Replicase polyprotein 1ab (pp1ab) (ORF1AB), ADENOSINE-5-DIPHOSPHORIBOSE (3 entities in total)
• Functional Keywords: protein-adp-ribose complex, structural genomics, structural proteomics in europe, marseilles structural genomics program @ afmb, msgp, viral protein
• Biological source: SARS coronavirus
• Cellular location: Non-structural protein 3: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 4: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 6: Host membrane; Multi-pass membrane protein (Potential). Non-structural protein 7: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 8: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 9: Host cytoplasm, host perinuclear region (By similarity). Non-structural protein 10: Host cytoplasm, host perinuclear region (By similarity). Helicase: Host endoplasmic reticulum-Golgi intermediate compartment (Potential). Uridylate-specific endoribonuclease: Host cytoplasm, host perinuclear region (By similarity): P59641
• Total number of polymer chains: 3
• Total formula weight: 59377.19

Authors

Egloff, M.P.,Malet, H.,Marseilles Structural Genomics Program @ AFMB (MSGP) (deposition date: 2005-12-08, release date: 2006-10-10, Last modification date: 2011-07-13)

• Primary citation: Egloff, M.P.,Malet, H.,Putics, A.,Heinonen, M.,Dutartre, H.,Frangeul, A.,Gruez, A.,Campanacci, V.,Cambillau, C.,Ziebuhr, J.,Ahola, T.,Canard, B.; Structural and functional basis for ADP-ribose and poly(ADP-ribose) binding by viral macro domains.; J.Virol., 80:8493-8502, 2006; PubMed: 16912299; DOI: 10.1128/JVI.00713-06

Experimental method

X-RAY DIFFRACTION (1.8 Å)