2F9B

Discovery of Novel Heterocyclic Factor VIIa Inhibitors

Summary for 2F9B

• Entry DOI: 10.2210/pdb2f9b/pdb
• Related: 1O5D
• Descriptor: Coagulation factor VII, Tissue factor, {5-(5-AMINO-1H-PYRROLO[3,2-B]PYRIDIN-2-YL)-6-HYDROXY-3'-NITRO-BIPHENYL-3-YL]-ACETIC ACID, ... (5 entities in total)
• Functional Keywords: serine protease, short hydrogen bond, active site-directed inhibitor, hydrolase-blood clotting complex, hydrolase/blood clotting
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P08709 P08709; Isoform 1: Membrane ; Single-pass type I membrane protein . Isoform 2: Secreted : P13726
• Total number of polymer chains: 3
• Total formula weight: 70294.04

Authors

Rai, R.,Kolesnikov, A.,Sprengeler, P.A.,Torkelson, S.,Ton, T.,Katz, B.A.,Yu, C.,Hendrix, J.,Shrader, W.D.,Stephens, R.,Cabuslay, R.,Sanford, E.,Young, W.B. (deposition date: 2005-12-05, release date: 2006-02-28, Last modification date: 2023-08-30)

• Primary citation: Rai, R.,Kolesnikov, A.,Sprengeler, P.A.,Torkelson, S.,Ton, T.,Katz, B.A.,Yu, C.,Hendrix, J.,Shrader, W.D.,Stephens, R.,Cabuslay, R.,Sanford, E.,Young, W.B.; Discovery of novel heterocyclic factor VIIa inhibitors.; Bioorg.Med.Chem.Lett., 16:2270-2273, 2006; PubMed: 16460932; DOI: 10.1016/j.bmcl.2006.01.017

Experimental method

X-RAY DIFFRACTION (2.54 Å)