2F7Z
Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine
Summary for 2F7Z
Entry DOI | 10.2210/pdb2f7z/pdb |
Related | 2F7E 2F7X |
Descriptor | cAMP-dependent protein kinase, alpha-catalytic subunit, PKI, inhibitory peptide, (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE (3 entities in total) |
Functional Keywords | protein kinase a, akt inhibitors, transferase |
Biological source | Bos taurus (cattle) |
Cellular location | Cytoplasm: P00517 |
Total number of polymer chains | 2 |
Total formula weight | 43299.52 |
Authors | Li, Q.,Woods, K.W.,Thomas, S.,Zhu, G.D.,Packard, G.,Fisher, J.,Li, T.,Gong, J.,Dinges, J.,Song, X.,Abrams, J.,Luo, Y.,Johnson, E.F.,Shi, Y.,Liu, X.,Klinghofer, V.,Des Jong, R.,Oltersdorf, T.,Stoll, V.S.,Jakob, C.G.,Rosenberg, S.H.,Giranda, V.L. (deposition date: 2005-12-01, release date: 2006-06-27, Last modification date: 2024-02-14) |
Primary citation | Li, Q.,Woods, K.W.,Thomas, S.,Zhu, G.D.,Packard, G.,Fisher, J.,Li, T.,Gong, J.,Dinges, J.,Song, X.,Abrams, J.,Luo, Y.,Johnson, E.F.,Shi, Y.,Liu, X.,Klinghofer, V.,Des Jong, R.,Oltersdorf, T.,Stoll, V.S.,Jakob, C.G.,Rosenberg, S.H.,Giranda, V.L. Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg.Med.Chem.Lett., 16:2000-2007, 2006 Cited by PubMed: 16413780DOI: 10.1016/j.bmcl.2005.12.065 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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