2F7Z

Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine

2F7Z の概要

関連するPDBエントリー2F7E 2F7X
分子名称cAMP-dependent protein kinase, alpha-catalytic subunit, PKI, inhibitory peptide, (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE (3 entities in total)
機能のキーワードprotein kinase a, akt inhibitors, transferase
由来する生物種Bos taurus (cattle)
細胞内の位置Cytoplasm P00517
ポリマー鎖数2
分子量合計43299.52
構造登録者
主引用文献
Li, Q.,Woods, K.W.,Thomas, S.,Zhu, G.D.,Packard, G.,Fisher, J.,Li, T.,Gong, J.,Dinges, J.,Song, X.,Abrams, J.,Luo, Y.,Johnson, E.F.,Shi, Y.,Liu, X.,Klinghofer, V.,Des Jong, R.,Oltersdorf, T.,Stoll, V.S.,Jakob, C.G.,Rosenberg, S.H.,Giranda, V.L.
Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer.
Bioorg.Med.Chem.Lett., 16:2000-2007, 2006
PubMed: 16413780 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmcl.2005.12.065
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (3 Å)
NMR情報
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers273.7%7.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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