2F7X
Protein Kinase A bound to (S)-2-(1H-Indol-3-yl)-1-[5-((E)-2-pyridin-4-yl-vinyl)-pyridin-3-yloxymethyl]-ethylamine
Summary for 2F7X
Entry DOI | 10.2210/pdb2f7x/pdb |
Related | 1YDS 2F7E 2F7Z |
Descriptor | cAMP-dependent protein kinase, alpha-catalytic subunit, PKI, inhibitory peptide, (1S)-2-(1H-INDOL-3-YL)-1-[({5-[(E)-2-PYRIDIN-4-YLVINYL]PYRIDIN-3-YL}OXY)METHYL]ETHYLAMINE, ... (4 entities in total) |
Functional Keywords | protein kinase a, akt inhibitors, transferase |
Biological source | Bos taurus (cattle) |
Cellular location | Cytoplasm: P00517 |
Total number of polymer chains | 2 |
Total formula weight | 43274.51 |
Authors | Li, Q.,Li, T.,Zhu, G.D.,Gong, J.,Claibone, A.,Dalton, C.,Luo, Y.,Johnson, E.F.,Shi, Y.,Liu, X.,Klinghofer, V.,Bauch, J.L.,Marsh, K.C.,Bouska, J.J.,Arries, S.,De Jong, R.,Oltersdorf, T.,Stoll, V.S.,Jakob, C.G.,Rosenberg, S.H.,Giranda, V.L. (deposition date: 2005-12-01, release date: 2006-06-27, Last modification date: 2024-02-14) |
Primary citation | Li, Q.,Li, T.,Zhu, G.D.,Gong, J.,Claibone, A.,Dalton, C.,Luo, Y.,Johnson, E.F.,Shi, Y.,Liu, X.,Klinghofer, V.,Bauch, J.L.,Marsh, K.C.,Bouska, J.J.,Arries, S.,De Jong, R.,Oltersdorf, T.,Stoll, V.S.,Jakob, C.G.,Rosenberg, S.H.,Giranda, V.L. Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. Bioorg.Med.Chem.Lett., 16:1679-1685, 2006 Cited by PubMed: 16403626DOI: 10.1016/j.bmcl.2005.12.017 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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