2F7I
Human transthyretin (TTR) complexed with diflunisal analogues- TTR. 2',6'-Difluorobiphenyl-4-carboxylic Acid
Summary for 2F7I
Entry DOI | 10.2210/pdb2f7i/pdb |
Descriptor | Transthyretin, 2',6'-DIFLUOROBIPHENYL-4-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | ttr, amyloid, transthyretin, hormone-growth factor complex, hormone/growth factor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P02766 |
Total number of polymer chains | 2 |
Total formula weight | 28023.12 |
Authors | Palaninathan, S.K.,Kelly, J.W.,Sacchettini, J.C. (deposition date: 2005-11-30, release date: 2005-12-13, Last modification date: 2023-08-23) |
Primary citation | Adamski-Werner, S.L.,Palaninathan, S.K.,Sacchettini, J.C.,Kelly, J.W. Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis. J.Med.Chem., 47:355-374, 2004 Cited by PubMed: 14711308DOI: 10.1021/jm030347n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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