2F44

Crystal Structure of the Zinc-bound Shank SAM domain

2F44 の概要

• エントリーDOI: 10.2210/pdb2f44/pdb
• 関連するPDBエントリー: 2F3N
• 分子名称: SH3 and multiple ankyrin repeat domains 3, ZINC ION, CHLORIDE ION, ... (4 entities in total)
• 機能のキーワード: post-synaptic density, sam domain, shank, scaffolding protein, zinc, structural protein
• 由来する生物種: Rattus norvegicus (Norway rat)
• 細胞内の位置: Cytoplasm: Q9JLU4
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 27578.90

構造登録者

Baron, M.K.,Bowie, J.U.,Faham, S. (登録日: 2005-11-22, 公開日: 2006-02-07, 最終更新日: 2023-08-23)

主引用文献

Baron, M.K.,Boeckers, T.M.,Vaida, B.,Faham, S.,Gingery, M.,Sawaya, M.R.,Salyer, D.,Gundelfinger, E.D.,Bowie, J.U.
An architectural framework that may lie at the core of the postsynaptic density.
Science, 311:531-535, 2006

PubMed Abstract: The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side by side. Zn2+, which is found in high concentrations in the PSD, binds tightly to Shank3 and may regulate assembly. Sheets of the Shank protein could form a platform for the construction of the PSD complex.

PubMed: 16439662
DOI: 10.1126/science.1118995

実験手法

X-RAY DIFFRACTION (2.4 Å)