2EU2

Human Carbonic Anhydrase II in complex with novel inhibitors

2EU2 の概要

• エントリーDOI: 10.2210/pdb2eu2/pdb
• 関連するPDBエントリー: 2EU3
• 分子名称: Carbonic anhydrase 2, ZINC ION, (R)-1-AMINO-1-[5-(DIMETHYLAMINO)-1,3,4-THIADIAZOL-2-YL]METHANESULFONAMIDE, ... (4 entities in total)
• 機能のキーワード: carbonic anhydrase ii proton transfer inhibitor, lyase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29591.77

構造登録者

Fisher, S.Z.,Govindasamy, L.,Boyle, N.,Agbandje-McKenna, M.,Silverman, D.N.,Blackburn, G.M.,McKenna, R. (登録日: 2005-10-28, 公開日: 2006-07-11, 最終更新日: 2023-08-23)

• 主引用文献: Fisher, S.Z.,Govindasamy, L.,Boyle, N.,Agbandje-McKenna, M.,Silverman, D.N.,Blackburn, G.M.,McKenna, R.; X-ray crystallographic studies reveal that the incorporation of spacer groups in carbonic anhydrase inhibitors causes alternate binding modes.; Acta Crystallogr.,Sect.F, 62:618-622, 2006; PubMed: 16820676; DOI: 10.1107/S1744309106020446

実験手法

X-RAY DIFFRACTION (1.15 Å)