2EG8

The crystal structure of E. coli dihydroorotase complexed with 5-fluoroorotic acid

Summary for 2EG8

Entry DOI	10.2210/pdb2eg8/pdb
Related	1XGE 2EG6 2EG7
Descriptor	Dihydroorotase, ZINC ION, 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ... (4 entities in total)
Functional Keywords	amidohydrolase, tim barrel, hydrolase
Biological source	Escherichia coli
Total number of polymer chains	2
Total formula weight	78151.97
Authors	Lee, M.,Maher, M.J.,Guss, J.M. (deposition date: 2007-02-28, release date: 2007-07-03, Last modification date: 2023-11-15)
Primary citation	Lee, M.,Chan, C.W.,Graham, S.C.,Christopherson, R.I.,Guss, J.M.,Maher, M.J. Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design J.Mol.Biol., 370:812-825, 2007 Cited by PubMed: 17550785 DOI: 10.1016/j.jmb.2007.05.019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation