2EG8
The crystal structure of E. coli dihydroorotase complexed with 5-fluoroorotic acid
Summary for 2EG8
Entry DOI | 10.2210/pdb2eg8/pdb |
Related | 1XGE 2EG6 2EG7 |
Descriptor | Dihydroorotase, ZINC ION, 5-FLUORO-2,6-DIOXO-1,2,3,6-TETRAHYDROPYRIMIDINE-4-CARBOXYLIC ACID, ... (4 entities in total) |
Functional Keywords | amidohydrolase, tim barrel, hydrolase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 78151.97 |
Authors | Lee, M.,Maher, M.J.,Guss, J.M. (deposition date: 2007-02-28, release date: 2007-07-03, Last modification date: 2023-11-15) |
Primary citation | Lee, M.,Chan, C.W.,Graham, S.C.,Christopherson, R.I.,Guss, J.M.,Maher, M.J. Structures of Ligand-free and Inhibitor Complexes of Dihydroorotase from Escherichia coli: Implications for Loop Movement in Inhibitor Design J.Mol.Biol., 370:812-825, 2007 Cited by PubMed: 17550785DOI: 10.1016/j.jmb.2007.05.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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