2EFT
Methanethiol-CYS 112 inhibition complex of E. coli ketoacyl synthase III (FABH) and Coenzyme A (high concentration (1.7mM) soak)
Summary for 2EFT
Entry DOI | 10.2210/pdb2eft/pdb |
Related | 1EBL 1HND 2GYO |
Descriptor | 3-oxoacyl-[acyl-carrier-protein] synthase 3, SULFATE ION, COENZYME A, ... (5 entities in total) |
Functional Keywords | fatty acid biosynthesis, alkyl-coa-disulfide, mechanism-based inhibitor, e. coli, half sites occupancy, transferase |
Biological source | Escherichia coli |
Cellular location | Cytoplasm: P0A6R0 |
Total number of polymer chains | 2 |
Total formula weight | 68149.93 |
Authors | Alhamadsheh, M.M.,Musayev, F.,Komissarov, A.A.,Sachdeva, S.,Wright, H.T.,Scarsdale, N.,Florova, G.,Reynolds, K.A. (deposition date: 2007-02-24, release date: 2007-06-12, Last modification date: 2023-10-25) |
Primary citation | Alhamadsheh, M.M.,Musayev, F.,Komissarov, A.A.,Sachdeva, S.,Wright, H.T.,Scarsdale, N.,Florova, G.,Reynolds, K.A. Alkyl-CoA Disulfides as Inhibitors and Mechanistic Probes for FabH Enzymes Chem.Biol., 14:513-524, 2007 Cited by PubMed: 17524982DOI: 10.1016/j.chembiol.2007.03.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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