2EFT

Methanethiol-CYS 112 inhibition complex of E. coli ketoacyl synthase III (FABH) and Coenzyme A (high concentration (1.7mM) soak)

2EFT の概要

• エントリーDOI: 10.2210/pdb2eft/pdb
• 関連するPDBエントリー: 1EBL 1HND 2GYO
• 分子名称: 3-oxoacyl-[acyl-carrier-protein] synthase 3, SULFATE ION, COENZYME A, ... (5 entities in total)
• 機能のキーワード: fatty acid biosynthesis, alkyl-coa-disulfide, mechanism-based inhibitor, e. coli, half sites occupancy, transferase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P0A6R0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68149.93

構造登録者

Alhamadsheh, M.M.,Musayev, F.,Komissarov, A.A.,Sachdeva, S.,Wright, H.T.,Scarsdale, N.,Florova, G.,Reynolds, K.A. (登録日: 2007-02-24, 公開日: 2007-06-12, 最終更新日: 2023-10-25)

• 主引用文献: Alhamadsheh, M.M.,Musayev, F.,Komissarov, A.A.,Sachdeva, S.,Wright, H.T.,Scarsdale, N.,Florova, G.,Reynolds, K.A.; Alkyl-CoA Disulfides as Inhibitors and Mechanistic Probes for FabH Enzymes; Chem.Biol., 14:513-524, 2007; PubMed: 17524982; DOI: 10.1016/j.chembiol.2007.03.013

実験手法

X-RAY DIFFRACTION (2 Å)