2EA3

Crystal Structure Of Cellulomonas Bogoriensis Chymotrypsin

Summary for 2EA3

Entry DOI	10.2210/pdb2ea3/pdb
Descriptor	Chymotrypsin, SULFATE ION (3 entities in total)
Functional Keywords	celloulomonas, chymotrypsin, protease, hydrolase
Biological source	Cellulomonas bogoriensis
Total number of polymer chains	1
Total formula weight	19078.85
Authors	Shaw, A.,Bott, R. (deposition date: 2007-01-30, release date: 2007-04-24, Last modification date: 2024-11-06)
Primary citation	Shaw, A.,Saldajeno, M.L.,Kolkman, M.A.,Jones, B.E.,Bott, R. Structure determination and analysis of a bacterial chymotrypsin from Cellulomonas bogoriensis Acta Crystallogr.,Sect.F, 63:266-269, 2007 Cited by PubMed Abstract: The crystal structure of a secreted chymotrypsin from the alkaliphile Cellulomonas bogoriensis has been determined using data to 1.78 A resolution and refined to a crystallographic R factor of 0.167. The crystal structure reveals a large P1 substrate-specificity pocket, as expected for chymotrypsins. The structure is compared with close structural homologues. This comparison does not reveal clear reasons for the alkali tolerance of the enzyme, but the greater compactness of the structure and lowered hydrogen bonding may play a role. PubMed: 17401191 DOI: 10.1107/S1744309107008937 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.78 Å)

Structure validation