2DZ7

DNA Octaplex Formation with an I-Motif of A-Quartets: The Revised Crystal Structure of d(GCGAAAGC)

2DZ7 の概要

• エントリーDOI: 10.2210/pdb2dz7/pdb
• 分子名称: DNA (5'-D(*DGP*DCP*DGP*DAP*DAP*DAP*DGP*DC)-3'), MAGNESIUM ION (3 entities in total)
• 機能のキーワード: a-quartet, dna octaplex, non-coding dna, vntr, dna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 2509.25

構造登録者

Sato, Y.,Mitomi, K.,Sumani, T.,Kondo, J.,Takenaka, A. (登録日: 2006-09-21, 公開日: 2007-08-14, 最終更新日: 2023-10-25)

主引用文献

Sato, Y.,Mitomi, K.,Sunami, T.,Kondo, J.,Takenaka, A.
DNA octaplex formation with an I-motif of water-mediated A-quartets: reinterpretation of the crystal structure of d(GCGAAAGC)
J.Biochem.(Tokyo), 140:759-762, 2006

PubMed Abstract: The crystal structure of the tetragonal form of d(gcGAAAgc) has been revised and reasonably refined including the disordered residues. The two DNA strands form a base-intercalated duplex, and the four duplexes are assembled according to the crystallographic 222 symmetry to form an octaplex. In the central region, the eight strands are associated by I-motif of double A-quartets. Furthermore, eight hydrated-magnesium cations link the four duplexes to support the octaplex formation. Based on these structural features, a proposal that folding of d(GAAA)n, found in the non-coding region of genomes, into an octaplex can induce slippage during replication to facilitate length polymorphism is presented.

PubMed: 17062599
DOI: 10.1093/jb/mvj213

実験手法

X-RAY DIFFRACTION (1.6 Å)