2DX1

Crystal structure of RhoGEF protein Asef

Summary for 2DX1

Entry DOI	10.2210/pdb2dx1/pdb
Descriptor	Rho guanine nucleotide exchange factor 4 (2 entities in total)
Functional Keywords	rho-gef, structural genomics, nppsfa, national project on protein structural and functional analyses, riken structural genomics/proteomics initiative, rsgi, signaling protein
Biological source	Homo sapiens (human)
Cellular location	Isoform 3: Cytoplasm: Q9NR80
Total number of polymer chains	1
Total formula weight	55623.78
Authors	Murayama, K.,Kato-Murayama, M.,Terada, T.,Shirouzu, M.,Yokoyama, S.,RIKEN Structural Genomics/Proteomics Initiative (RSGI) (deposition date: 2006-08-22, release date: 2007-01-02, Last modification date: 2011-07-13)
Primary citation	Murayama, K.,Shirouzu, M.,Kawasaki, Y.,Kato-Murayama, M.,Hanawa-Suetsugu, K.,Sakamoto, A.,Katsura, Y.,Suenaga, A.,Toyama, M.,Terada, T.,Taiji, M.,Akiyama, T.,Yokoyama, S. Crystal structure of the rac activator, Asef, reveals its autoinhibitory mechanism J.Biol.Chem., 282:4238-4242, 2007 Cited by PubMed: 17190834 DOI: 10.1074/jbc.C600234200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.36 Å)

Structure validation