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2DW1

Crystal structure of VAP2 from Crotalus atrox venom (Form 2-2 crystal)

2DW1 の概要
エントリーDOI10.2210/pdb2dw1/pdb
関連するPDBエントリー2DW0 2DW2
分子名称Catrocollastatin, alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
機能のキーワードapoptotic toxin, svmp, metalloproteinase, apoptosis, toxin
由来する生物種Crotalus atrox (western diamondback rattlesnake)
細胞内の位置Secreted: Q90282
タンパク質・核酸の鎖数2
化学式量合計96292.96
構造登録者
Takeda, S.,Igarashi, T.,Araki, S. (登録日: 2006-08-02, 公開日: 2007-07-10, 最終更新日: 2024-10-23)
主引用文献Igarashi, T.,Araki, S.,Mori, H.,Takeda, S.
Crystal structures of catrocollastatin/VAP2B reveal a dynamic, modular architecture of ADAM/adamalysin/reprolysin family proteins
Febs Lett., 581:2416-2422, 2007
Cited by
PubMed Abstract: Catrocollastatin/vascular apoptosis-inducing protein (VAP)2B is a metalloproteinase from Crotalus atrox venom, possessing metalloproteinase/disintegrin/cysteine-rich (MDC) domains that bear the typical domain architecture of a disintegrin and metalloproteinase (ADAM)/adamalysin/reprolysin family proteins. Here we describe crystal structures of catrocollastatin/VAP2B in three different crystal forms, representing the first reported crystal structures of a member of the monomeric class of this family of proteins. The overall structures show good agreement with both monomers of atypical homodimeric VAP1. Comparison of the six catrocollastatin/VAP2B monomer structures and the structures of VAP1 reveals a dynamic, modular architecture that may be important for the functions of ADAM/adamalysin/reprolysin family proteins.
PubMed: 17485084
DOI: 10.1016/j.febslet.2007.04.057
主引用文献が同じPDBエントリー
実験手法
X-RAY DIFFRACTION (2.5 Å)
構造検証レポート
Validation report summary of 2dw1
検証レポート(詳細版)ダウンロードをダウンロード

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件を2025-07-09に公開中

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