2D47

MOLECULAR STRUCTURE OF A COMPLETE TURN OF A-DNA

2D47 の概要

• エントリーDOI: 10.2210/pdb2d47/pdb
• 分子名称: DNA (5'-D(*CP*CP*CP*CP*CP*GP*CP*GP*GP*GP*GP*G)-3'), SPERMINE (3 entities in total)
• 機能のキーワード: a-dna, double helix, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7533.08

構造登録者

Verdaguer, N.,Aymami, J.,Fernandez-Forner, D.,Fita, I.,Coll, M.,Huynh-Dinh, T.,Igolen, J.,Subirana, J.A. (登録日: 1991-10-02, 公開日: 1991-10-02, 最終更新日: 2024-02-14)

主引用文献

Verdaguer, N.,Aymami, J.,Fernandez-Forner, D.,Fita, I.,Coll, M.,Huynh-Dinh, T.,Igolen, J.,Subirana, J.A.
Molecular structure of a complete turn of A-DNA.
J.Mol.Biol., 221:623-635, 1991

PubMed Abstract: We have determined the crystal structure of the dodecamer d(CCCCCGCGGGGG), showing for the first time a complete turn of A-DNA. It has average structural parameters similar to those determined in fibres. Nevertheless it shows a considerable local variation in structure which is in part associated with the presence of a bound spermine molecule. We conclude that the local DNA conformation does not only depend on the base sequence, but may be strongly modified upon interaction with other molecules. In particular, the CpG sequence, which is found in hypersensitive regions of the genome, appears to be able to easily change its conformation under external influences.

PubMed: 1920437
DOI: 10.1016/0022-2836(91)80077-8

実験手法

X-RAY DIFFRACTION (2 Å)