2D3U
X-ray crystal structure of hepatitis C virus RNA dependent RNA polymerase in complex with non-nucleoside analogue inhibitor
Summary for 2D3U
Entry DOI | 10.2210/pdb2d3u/pdb |
Related | 2D3Z 2D41 |
Descriptor | polyprotein, 5-(4-CYANOPHENYL)-3-{[(2-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID (3 entities in total) |
Functional Keywords | hepatitis c virus, rna-dependent rna polymerase, enzyme inhibition, transferase |
Biological source | Hepatitis C virus |
Cellular location | Virion : Q99AU2 |
Total number of polymer chains | 2 |
Total formula weight | 127346.05 |
Authors | Biswal, B.K.,Wang, M.,Cherney, M.M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Bedard, J.,James, M.N.G. (deposition date: 2005-10-02, release date: 2006-08-01, Last modification date: 2017-10-11) |
Primary citation | Biswal, B.K.,Wang, M.,Cherney, M.M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Bedard, J.,James, M.N.G. Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition J.Mol.Biol., 361:33-45, 2006 Cited by PubMed: 16828488DOI: 10.1016/j.jmb.2006.05.074 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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