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2D3U

X-ray crystal structure of hepatitis C virus RNA dependent RNA polymerase in complex with non-nucleoside analogue inhibitor

Summary for 2D3U
Entry DOI10.2210/pdb2d3u/pdb
Related2D3Z 2D41
Descriptorpolyprotein, 5-(4-CYANOPHENYL)-3-{[(2-METHYLPHENYL)SULFONYL]AMINO}THIOPHENE-2-CARBOXYLIC ACID (3 entities in total)
Functional Keywordshepatitis c virus, rna-dependent rna polymerase, enzyme inhibition, transferase
Biological sourceHepatitis C virus
Cellular locationVirion : Q99AU2
Total number of polymer chains2
Total formula weight127346.05
Authors
Biswal, B.K.,Wang, M.,Cherney, M.M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Bedard, J.,James, M.N.G. (deposition date: 2005-10-02, release date: 2006-08-01, Last modification date: 2017-10-11)
Primary citationBiswal, B.K.,Wang, M.,Cherney, M.M.,Chan, L.,Yannopoulos, C.G.,Bilimoria, D.,Bedard, J.,James, M.N.G.
Non-nucleoside Inhibitors Binding to Hepatitis C Virus NS5B Polymerase Reveal a Novel Mechanism of Inhibition
J.Mol.Biol., 361:33-45, 2006
Cited by
PubMed: 16828488
DOI: 10.1016/j.jmb.2006.05.074
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

217705

건을2024-03-27부터공개중

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