2D1J

Factor Xa in complex with the inhibitor 2-[[4-[(5-chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide

Summary for 2D1J

• Entry DOI: 10.2210/pdb2d1j/pdb
• Related: 1V3X 1WU1
• Descriptor: Coagulation factor X, heavy chain, Coagulation factor X, light chain, CALCIUM ION, ... (5 entities in total)
• Functional Keywords: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P00742 P00742
• Total number of polymer chains: 2
• Total formula weight: 32750.64

Authors

Suzuki, M. (deposition date: 2005-08-24, release date: 2006-08-24, Last modification date: 2023-10-25)

• Primary citation: Komoriya, S.,Haginoya, N.,Kobayashi, S.,Nagata, T.,Mochizuki, A.,Suzuki, M.,Yoshino, T.,Horino, H.,Nagahara, T.,Suzuki, M.,Isobe, Y.,Furugoori, T.; Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites.; Bioorg.Med.Chem., 13:3927-3954, 2005; PubMed: 15911309; DOI: 10.1016/j.bmc.2005.04.006

Experimental method

X-RAY DIFFRACTION (2.2 Å)