2D1J

Factor Xa in complex with the inhibitor 2-[[4-[(5-chloroindol-2-yl)sulfonyl]piperazin-1-yl] carbonyl]thieno[3,2-b]pyridine n-oxide

2D1J の概要

関連するPDBエントリー1WU1 1V3X
分子名称Coagulation factor X, heavy chain, Coagulation factor X, light chain, CALCIUM ION, ... (5 entities in total)
機能のキーワードglycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding
由来する生物種Homo sapiens (human)
細胞内の位置Secreted P00742 P00742
ポリマー鎖数2
分子量合計32750.64
構造登録者
Suzuki, M. (登録日: 2005-08-24, 公開日: 2006-08-24, 最終更新日: 2011-07-13)
主引用文献
Komoriya, S.,Haginoya, N.,Kobayashi, S.,Nagata, T.,Mochizuki, A.,Suzuki, M.,Yoshino, T.,Horino, H.,Nagahara, T.,Suzuki, M.,Isobe, Y.,Furugoori, T.
Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites.
Bioorg.Med.Chem., 13:3927-3954, 2005
PubMed: 15911309 (主引用文献が同じPDBエントリー)
DOI: 10.1016/j.bmc.2005.04.006
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.2 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers700.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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件を2020-07-15に公開中