2CW3

X-ray structure of PmSOD2, superoxide dismutase from Perkinsus marinus

2CW3 の概要

• エントリーDOI: 10.2210/pdb2cw3/pdb
• 関連するPDBエントリー: 2cw2
• 分子名称: iron superoxide dismutase, FE (III) ION (3 entities in total)
• 機能のキーワード: sod, oxidoreductase
• 由来する生物種: Perkinsus marinus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 63428.19

構造登録者

Asojo, O.A.,Schott, E.J.,Vasta, G.R.,Silva, A.M. (登録日: 2005-06-16, 公開日: 2006-07-04, 最終更新日: 2024-03-13)

主引用文献

Asojo, O.A.,Schott, E.J.,Vasta, G.R.,Silva, A.M.
Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus
ACTA CRYSTALLOGR.,SECT.F, 62:1072-1075, 2006

PubMed Abstract: Perkinsus marinus, a facultative intracellular parasite of the eastern oyster Crassostrea virginica, is responsible for mass mortalities of oyster populations. P. marinus trophozoites survive and proliferate within oyster hemocytes, invading most tissues and fluids, thus causing a systemic infection that eventually kills the host. The phagocytosis of P. marinus trophozoites lacks a respiratory burst, suggesting that the parasite has mechanisms that actively abrogate the host's oxidative defense responses. One mechanism and the first line of defense against oxidative damage is the dismutation of superoxide radical to molecular oxygen and hydrogen peroxide by superoxide dismutases (SODs). P. marinus possesses two iron-cofactored SODs, PmSOD1 and PmSOD2. Here, the crystallization and X-ray structures of both PmSOD1 and PmSOD2 are presented.

PubMed: 17077482
DOI: 10.1107/S1744309106040425

実験手法

X-RAY DIFFRACTION (2.5 Å)